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Trial Net Type 1 Diabetes Mixed Meal Toleance Test (MMTT) - Glucagon Stimulation Test (GST) Research Study

RECRUITMENT FOR THIS STUDY IS NOW COMPLETE

Type 1 diabetes is a life-long condition that can affect both children and adults. It occurs when the body attacks and destroys the cells in the pancreas that make insulin. The body needs insulin, a hormone, to turn food into energy. Because of the attack on beta cells, people with diabetes produce decreasing amounts of insulin over time.

When we conduct clinical research in people with type 1 diabetes, it is important for us to know how much insulin is still being produced by the pancreas. Currently, two tests, a Mixed Meal Tolerance Test (MMTT) and a Glucagon Stimulation Test (GST) have been used to measure insulin production. The aim of this study is to compare these two tests to find out which is a better measure of insulin secretion, and which test people tolerate better.

This test will help us develop a standardised way to test for insulin production in pre-clinical and clinical type 1 diabetes. A standardised test of this kind will be invaluable both for planning intervention and prevention studies in type 1 diabetes and for measureing their outcome.

Click here to read more about the TrialNet MMTT-GST Study, or follow one of the links below to learn about specific aspects of the trial.

Results of this trial were presented as a Poster at the 2006 Australian Diabetes Society Meeting. Read the text of the Poster here.

Learn about our other TrialNet Studies: the Natural History Study and the Rituximab Trial

The MMTT-GST Research Study is supported by Type 1 Diabetes TrialNet (click on icon below to learn more about TrialNet)

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