RECRUITMENT FOR THIS STUDY IS NOW COMPLETE
WHAT
IS TYPE 1 DIABETES?
Type
1 diabetes is a life-long condition that can affect both children and
adults. It occurs when the body attacks and destroys the cells in the
pancreas that make insulin. The body needs insulin, a hormone, to turn
food into energy.
WHAT
IS TYPE 1 DIABETES TRIALNET?
Type
1 Diabetes TrialNet is a network of clinical centres dedicated to conducting
diabetes prevention research and studying new therapies for people with
newly diagnosed diabetes. TrialNet centres in Australia and New Zealand
work in cooperation with centres located throughout the United States,
Canada, and Europe. TrialNet researchers are experts in both diabetes
and the body’s immune system. They share common scientific goals
related to the study, treatment and prevention of type 1 diabetes.
TrialNet
is supported by the National Institutes of Health, which is part of the
United States federal government. It is also supported by two major diabetes
organizations, the Juvenile Diabetes Research Foundation and the American
Diabetes Association.
INFORMATION
ABOUT THE MMTT-GST RESEARCH STUDY
The purpose of this study is to compare two tests that measure C-peptide. These tests are used in diabetes research to find out how much insulin is produced by the pancreas in a person with type 1 diabetes.
The two tests being studied are the Mixed Meal Tolerance Test (MMTT) and the Glucagon Stimulation Test (GST).
We are interested in finding out which test is a better measure of insulin secretion and which test people tolerate better.
Who
is eligible to participate?
You may participate if you:
are between 8 and 35 years of age;
have had type 1 diabetes for at least 1 month but no more than 3 years;
weigh more than 30 kilograms
are not pregnant or planning to become pregnant, and
are willing to travel to Royal Melbourne Hospital for at least four visits.
What is a Mixed Meal Tolerance Test?
A Mixed Meal Tolerance Test involves taking a drink called BOOST (it tastes like a milkshake).
BOOST will raise your blood sugar, causing your body to release insulin. We will take several blood samples form you over a 2 hour period. To make the blood sampling easier, we will place a needle in a vein in your arm and this will stay in place until the end of the test. You will have this test twice, on two separate days.
What is a Glucagon Stimulation Test?
A Glucagon Stimulation Test involves being given glucagon through through a needle in a vein in your arm and then having several blood samples taken through the same needle.
Glucagon is a hormone that will raise your blood glucose, causing your body to release insulin. After you have been given the glucagon, blood will be taken five times over the next ten minutes. You will have this test twice, on two separate days.
Are there any risks?
The risks are minimal, but may include:
bruising from getting blood taken
nausea/upset stomach from the glucagon
There is no charge for study testing.
Will I receive any compensation or reimbursement?
You will receive $60 for each visit which includes reimbursement for travel expenses.
WHO DO I CONTACT TO FIND OUT MORE ABOUT THE MMTT-GST RESEARCH STUDY?
Please
contact Chris Perry at The Royal Melbourne Hospital on: Ph: (03) 9342 7063.
You can also visit the TrialNet Website at www.diabetestrialnet.com
